The average bus between Pisa and Rome, Termini takes 5h 35m and the fastest bus takes 4h 56m. The bus service runs several times per day from Pisa to Rome, Termini. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Pisa and Rome, Termini. The earliest departure is at 12:25 AM at night, and the last departure from Pisa is at 10:00 PM which arrives into Rome, Termini at 2:56 AM. All services require a transfer, and take on average 5h 35m. The schedules shown below are for the next available departures.

6h 11m • 1 change

5h 13m • 1 change

5h 39m • 1 change
Arrives next day

4h 56m • 1 change

6h 11m • 1 change

5h 13m • 1 change

5h 51m • 1 change

5h 39m • 1 change

6h 6m • 1 change

5h 16m • 1 change

5h 45m • 1 change

5h 46m • 1 change

6h 12m • 1 change

5h 16m • 1 change

5h 40m • 1 change

5h 46m • 1 change

6h 11m • 1 change

5h 13m • 1 change

5h 51m • 1 change

5h 39m • 1 change
Want to know about travelling from Pisa to Rome, Termini? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Pisa to Rome, Termini. However, there are services departing from Pisa station and arriving at Rome, Termini station via Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 5h 35m.
Pisa to Rome, Termini bus services, operated by FlixBus, depart from Pisa station.
Pisa to Rome, Termini bus services, operated by FlixBus, arrive at Roma, Autostazione Tiburtina station.
The distance between Pisa and Rome, Termini is 263.8 km. The road distance is 361 km.
FlixBus operates a bus from Pisa to Roma, Autostazione Tiburtina 3 times a day. Tickets cost €25–45 and the journey takes 5h 30m.