The average bus between Otranto and Monopoli takes 4h 54m and the fastest bus takes 3h 59m. The bus service runs several times per day from Otranto to Monopoli. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Otranto and Monopoli. The earliest departure is at 9:40 AM in the morning, and the last departure from Otranto is at 6:48 PM which arrives into Monopoli at 12:49 AM. All services require a transfer, and take on average 4h 54m. The schedules shown below are for the next available departures.

3h 59m • 1 change

4h 44m • 1 change
Arrives next day

6h 1m • 1 change

3h 59m • 1 change

4h 44m • 1 change
Arrives next day

6h 1m • 1 change

3h 59m • 1 change

4h 44m • 1 change
Arrives next day

6h 1m • 1 change

3h 59m • 1 change

4h 44m • 1 change
Arrives next day

6h 1m • 1 change
Want to know about travelling from Otranto to Monopoli? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Otranto to Monopoli. However, there are services departing from Otranto station and arriving at Monopoli station via Lecce - City Terminal. The journey, including transfers, takes approximately 4h 54m.
Otranto to Monopoli bus services, operated by Salento in bus, depart from Otranto - Stazione FSE station.
Otranto to Monopoli bus services, operated by Salento in bus, arrive at Monopoli station.
Book your Otranto to Monopoli bus tickets online with Salento in bus and FlixBus.
The distance between Otranto and Monopoli is 134.3 km. The road distance is 159 km.
You can take a bus from Otranto - Stazione FSE to Monopoli via Lecce in around 4h 16m.