The average bus between Otranto and Milan takes 20h 21m and the fastest bus takes 15h 35m. The bus service runs several times per day from Otranto to Milan. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Otranto and Milan. The earliest departure is at 2:10 PM in the afternoon, and the last departure from Otranto is at 6:48 PM which arrives into Milan at 7:55 PM. All services require a transfer, and take on average 20h 21m. The schedules shown below are for the next available departures.
Arrives next day

15h 35m • 1 change
Arrives next day

25h 7m • 1 change
Arrives next day

15h 35m • 1 change
Arrives next day

25h 7m • 1 change
Arrives next day

15h 35m • 1 change
Arrives next day

25h 7m • 1 change
Arrives next day

15h 35m • 1 change
Arrives next day

25h 7m • 1 change
Want to know about travelling from Otranto to Milan? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Otranto to Milan. However, there are services departing from Otranto station and arriving at Milan station via Lecce - City Terminal. The journey, including transfers, takes approximately 20h 21m.
Otranto to Milan bus services, operated by Salento in bus, depart from Otranto - Stazione FSE station.
Otranto to Milan bus services, operated by Salento in bus, arrive at Milano, San Donato M3 station.
Book your Otranto to Milan bus tickets online with Salento in bus and FlixBus.
The distance between Otranto and Milan is 960.5 km. The road distance is 1,092 km.
You can take a bus from Otranto - Stazione FSE to Milano, San Donato M3 via Lecce in around 15h 57m.