The average bus between Niagara Falls and Depew takes 2h 20m and the fastest bus takes 1h 48m. The bus service runs several times per day from Niagara Falls to Depew. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Niagara Falls and Depew. The earliest departure is at 12:03 AM at night, and the last departure from Niagara Falls is at 5:09 PM which arrives into Depew at 7:24 PM. All services require a transfer, and take on average 2h 20m. The schedules shown below are for the next available departures.

1h 52m • 1 change

1h 53m • 1 change

2h 6m • 1 change

2h 15m • 1 change

5h 34m • 1 change

1h 49m • 1 change

1h 49m • 1 change

1h 48m • 1 change

5h 14m • 1 change

1h 49m • 1 change

1h 49m • 1 change

1h 48m • 1 change

5h 14m • 1 change

1h 49m • 1 change

1h 49m • 1 change

1h 48m • 1 change

5h 14m • 1 change

1h 49m • 1 change

1h 49m • 1 change

1h 48m • 1 change
Want to know about travelling from Niagara Falls to Depew? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Niagara Falls to Depew. However, there are services departing from Niagara Falls station and arriving at Depew station via Ellicott Street & MTC Static. The journey, including transfers, takes approximately 2h 20m.
Niagara Falls to Depew bus services, operated by NFTA, depart from Pine Avenue & Main Street station.
Niagara Falls to Depew bus services, operated by NFTA, arrive at Broadway & Elwood Avenue station.
The distance between Niagara Falls and Depew is 36.4 km. The road distance is 67 km.
You can take a bus from Pine Avenue & Main Street to Broadway & Elwood Avenue via Ellicott Street & MTC Static in around 3h.