The average bus between Mannheim and Essen takes 5h 57m and the fastest bus takes 5h 10m. The bus service runs several times per day from Mannheim to Essen. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Mannheim and Essen. The earliest departure is at 12:55 AM at night, and the last departure from Mannheim is at 4:05 PM which arrives into Essen at 9:55 PM. All services require a transfer, and take on average 5h 57m. The schedules shown below are for the next available departures.

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9h 35m • 1 change

10h 50m • 1 change

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7h 10m • 1 change
Want to know about travelling from Mannheim to Essen? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Mannheim to Essen. However, there are services departing from Mannheim station and arriving at Essen station via Düsseldorf central bus station station. The journey, including transfers, takes approximately 5h 57m.
Mannheim to Essen bus services, operated by FlixBus, depart from Mannheim central bus station.
Mannheim to Essen bus services, operated by FlixBus, arrive at Düsseldorf central bus station.
Book your Mannheim to Essen bus tickets online with FlixBus and BlaBlaCar Bus.
The distance between Mannheim and Essen is 241.8 km. The road distance is 320 km.
FlixBus operates a bus from Mannheim central bus station to Düsseldorf central bus station every 3 hours. Tickets cost €20–35 and the journey takes 4h 15m.