The average bus between Manisa and Istanbul takes 7h 58m and the fastest bus takes 6h 15m. There is a bus service every few hours from Manisa to Istanbul. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 2 hours between Manisa and Istanbul. The earliest departure is at 1:50 AM at night, and the last departure from Manisa is at 11:59 PM which arrives into Istanbul at 8:00 AM. All services require a transfer, and take on average 7h 58m. The schedules shown below are for the next available departures.

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Want to know about travelling from Manisa to Istanbul? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Manisa to Istanbul. However, there are services departing from Manisa station and arriving at Istanbul station via Balıkesir bus station station. The journey, including transfers, takes approximately 7h 58m.
Manisa to Istanbul bus services, operated by Efe Tur, depart from Manisa bus station.
Manisa to Istanbul bus services, operated by Efe Tur, arrive at İstanbul Esenler station.
Book your Manisa to Istanbul bus tickets online with Efe Tur, Balikesir Uludağ and 3 other operators.
The distance between Manisa and Istanbul is 297.1 km. The road distance is 447 km.
You can take a bus from Manisa bus station to İstanbul Esenler via Balıkesir in around 7h 37m.