The average bus between Manisa and Istanbul takes 7h 48m and the fastest bus takes 6h 45m. The bus service runs several times per day from Manisa to Istanbul. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 2 hours between Manisa and Istanbul. The earliest departure is at 1:50 AM at night, and the last departure from Manisa is at 9:45 PM which arrives into Istanbul at 5:30 AM. All services require a transfer, and take on average 7h 48m. The schedules shown below are for the next available departures.

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Want to know about travelling from Manisa to Istanbul? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Manisa to Istanbul. However, there are services departing from Manisa station and arriving at Istanbul station via Balıkesir bus station station. The journey, including transfers, takes approximately 7h 48m.
Manisa to Istanbul bus services, operated by Balikesir Uludağ, depart from Manisa bus station.
Manisa to Istanbul bus services, operated by Balikesir Uludağ, arrive at İstanbul Esenler bus station.
Book your Manisa to Istanbul bus tickets online with Balikesir Uludağ, Kamil Koç and Pamukkale Turizm.
The distance between Manisa and Istanbul is 297.1 km. The road distance is 445 km.
You can take a bus from Manisa bus station to İstanbul Esenler bus station via Balıkesir bus station in around 7h 44m.