The average bus between Manhattan and Frederick takes 6h 45m and the fastest bus takes 6h 30m. The bus service runs several times per day from Manhattan to Frederick. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Manhattan and Frederick. The earliest departure is at 12:01 AM at night, and the last departure from Manhattan is at 2:00 PM which arrives into Frederick at 8:30 PM. All services require a transfer, and take on average 6h 45m. The schedules shown below are for the next available departures.

6h 39m • 1 change

6h 30m • 1 change

7h 20m • 1 change

6h 30m • 1 change

6h 39m • 1 change

6h 30m • 1 change

7h 20m • 1 change

6h 30m • 1 change

6h 39m • 1 change

6h 30m • 1 change

7h 20m • 1 change

6h 30m • 1 change
Want to know about travelling from Manhattan to Frederick? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Manhattan to Frederick. However, there are services departing from Manhattan station and arriving at Frederick station via Baltimore Downtown Bus Station station. The journey, including transfers, takes approximately 6h 45m.
Manhattan to Frederick bus services, operated by Greyhound USA, depart from Port Authority Bus Terminal station.
Manhattan to Frederick bus services, operated by Greyhound USA, arrive at Frederick Bus Station.
Book your Manhattan to Frederick bus tickets online with Greyhound USA, BayRunner Shuttle and Peter Pan Bus Lines.
The distance between Manhattan and Frederick is 330.1 km. The road distance is 458 km.
You can take a bus from Port Authority Bus Terminal to Frederick Bus Station via Baltimore Downtown Bus Terminal, Baltimore, MD in around 5h 15m.