The average bus between Manchester and Spitalfields takes 5h 53m and the fastest bus takes 5h 27m. There is a bus service every few hours from Manchester to Spitalfields. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 2 hours between Manchester and Spitalfields. The earliest departure is at 2:50 AM at night, and the last departure from Manchester is at 11:59 PM which arrives into Spitalfields at 7:05 AM. All services require a transfer, and take on average 5h 53m. The schedules shown below are for the next available departures.

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Want to know about travelling from Manchester to Spitalfields? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Manchester to Spitalfields. However, there are services departing from Manchester station and arriving at Spitalfields station via London Victoria. The journey, including transfers, takes approximately 5h 53m.
Manchester to Spitalfields bus services, operated by FlixBus, depart from Manchester, Shudehill Interchange station.
Manchester to Spitalfields bus services, operated by FlixBus, arrive at London Victoria station.
Book your Manchester to Spitalfields bus tickets online with FlixBus and National Express.
The distance between Manchester and Spitalfields is 262.6 km. The road distance is 322 km.
FlixBus operates a bus from Manchester, Shudehill Interchange to London Victoria hourly. Tickets cost £19–35 and the journey takes 4h 40m.