The average bus between Mainz and Siegen takes 4h 26m and the fastest bus takes 2h 45m. The bus service runs several times per day from Mainz to Siegen. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Mainz and Siegen. The earliest departure is at 5:10 AM in the morning, and the last departure from Mainz is at 8:00 PM which arrives into Siegen at 12:35 AM. All services require a transfer, and take on average 4h 26m. The schedules shown below are for the next available departures.

6h • 1 change

2h 45m • 1 change
Arrives next day

4h 35m • 1 change

6h • 1 change

2h 45m • 1 change
Arrives next day

4h 35m • 1 change

6h • 1 change

2h 45m • 1 change
Arrives next day

4h 35m • 1 change

6h • 1 change

2h 45m • 1 change
Arrives next day

4h 35m • 1 change
Want to know about travelling from Mainz to Siegen? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Mainz to Siegen. However, there are services departing from Mainz station and arriving at Siegen station via Frankfurt central train station station. The journey, including transfers, takes approximately 4h 26m.
Mainz to Siegen bus services, operated by FlixBus, depart from Mainz central train station.
Mainz to Siegen bus services, operated by FlixBus, arrive at Siegen station.
Book your Mainz to Siegen bus tickets online with FlixBus.
The distance between Mainz and Siegen is 100.7 km. The road distance is 171 km.
You can take a bus from Mainz central train station to Siegen via Frankfurt central train station in around 4h.