The average bus between Maine and Hyannis takes 5h 37m and the fastest bus takes 4h 42m. The bus service runs several times per day from Maine to Hyannis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 2 hours between Maine and Hyannis. The earliest departure is at 5:33 AM in the morning, and the last departure from Maine is at 10:15 PM which arrives into Hyannis at 8:15 AM. All services require a transfer at Portland, ME and take an average of 5h 37m. The schedules shown below are for the next available departures.


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5h 20m • 2 changesWant to know about travelling from Maine to Hyannis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Maine to Hyannis. However, there are services departing from Portland, ME station and arriving at Hyannis Transportation Center station via Boston, MA - South Station. The journey, including transfers, takes approximately 5h 37m.
Maine to Hyannis bus services, operated by Concord Coach Lines, depart from Portland, ME station.
Maine to Hyannis bus services, operated by Plymouth & Brockton, arrive at Hyannis Transportation Center station.
The distance between Maine and Hyannis is 465.2 km. The road distance is 282 km.
You can take a bus from Portland Public Library to Hyannis Transportation Center via Portland, ME, Boston, MA - South Station, and Boston South Buses in around 5h 4m.