The average bus between Madison and Saint Charles takes 18h 53m and the fastest bus takes 14h 14m. The bus service runs several times per day from Madison to Saint Charles. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Madison and Saint Charles. The earliest departure is at 6:45 AM in the morning, and the last departure from Madison is at 5:55 PM which arrives into Saint Charles at 8:09 AM. All services require a transfer at Chicago Bus Station and take an average of 18h 53m. The schedules shown below are for the next available departures.
Arrives next day



23h 24m • 3 changes
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15h 14m • 3 changes
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23h 24m • 3 changes
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15h 14m • 3 changes
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23h 4m • 3 changes
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14h 14m • 3 changes
Arrives next day



23h 4m • 3 changes
Arrives next day



14h 14m • 3 changes
Want to know about travelling from Madison to Saint Charles? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Madison to Saint Charles. However, there are services departing from Madison station and arriving at Saint Charles station via Chicago Bus Station station. The journey, including transfers, takes approximately 18h 53m.
Madison to Saint Charles bus services, operated by Flixbus USA, depart from Madison station.
Madison to Saint Charles bus services, operated by Flixbus USA, arrive at St Louis Bus Station.
The distance between Madison and Saint Charles is 485.5 km. The road distance is 789 km.
You can take a bus from Madison to 4375 Rider Trail North Sb via Chicago Bus Station, St Louis Bus Station, Civic Center Transit Center, and North Hanley Transit Center in around 12h 3m.