The average bus between Lyon and Vesoul takes 6h 22m and the fastest bus takes 4h 5m. The bus service runs several times per day from Lyon to Vesoul. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Lyon and Vesoul. The earliest departure is at 5:20 AM in the morning, and the last departure from Lyon is at 6:05 PM which arrives into Vesoul at 7:21 AM. All services require a transfer, and take on average 6h 22m. The schedules shown below are for the next available departures.

5h 51m • 1 change

6h 16m • 1 change

4h 5m • 1 change
Arrives next day

14h 25m • 1 change

5h 51m • 1 change

6h 16m • 1 change

4h 5m • 1 change
Arrives next day

13h 16m • 1 change

4h 21m • 1 change

5h 11m • 1 change

4h 5m • 1 change
Arrives next day

13h 16m • 1 change
Want to know about travelling from Lyon to Vesoul? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Lyon to Vesoul. However, there are services departing from Lyon station and arriving at Vesoul station via Besançon. The journey, including transfers, takes approximately 6h 22m.
Lyon to Vesoul bus services, operated by FlixBus, depart from Lyon station.
Lyon to Vesoul bus services, operated by FlixBus, arrive at Pôle Multimodal station.
The distance between Lyon and Vesoul is 231 km. The road distance is 272 km.
You can take a bus from Lyon to Pôle Multimodal via PEM Viotte in around 4h 40m.