Rome2Rio

Lyon to Isernia buses

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Trip Overview

The average bus between Lyon and Isernia takes 19h 42m and the fastest bus takes 17h 10m. The bus service runs several times per day from Lyon to Isernia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

19h 42m
Duration
1,184 km
Distance
€105
Average price
Twice daily
Frequency

Lyon to Isernia bus times

Buses run twice daily between Lyon and Isernia. The earliest departure is at 1:30 AM at night, and the last departure from Lyon is at 3:30 PM which arrives into Isernia at 1:25 PM. All services require a transfer, and take on average 19h 42m. The schedules shown below are for the next available departures.

Departing Friday, November 13, 2026

  •  → 

    FlixBusATM Azienda di Trasporti Molisana S.p.A.17h 10m • 1 change
  •  → 

    Arrives next day

    Itabus S.p.A.ATM Azienda di Trasporti Molisana S.p.A.21h 55m • 1 change

Departing Saturday, November 14, 2026

  •  → 

    FlixBusATM Azienda di Trasporti Molisana S.p.A.17h 10m • 1 change
  •  → 

    Arrives next day

    Itabus S.p.A.FlixBus25h 45m • 1 change

Departing Sunday, November 15, 2026

  •  → 

    FlixBusATM Azienda di Trasporti Molisana S.p.A.17h 50m • 1 change
  •  → 

    BlaBlaCar BusATM Azienda di Trasporti Molisana S.p.A.17h 35m • 1 change
  •  → 

    Arrives next day

    Itabus S.p.A.ATM Azienda di Trasporti Molisana S.p.A.21h 55m • 1 change

Departing Monday, November 16, 2026

  •  → 

    FlixBusATM Azienda di Trasporti Molisana S.p.A.17h 10m • 1 change
  •  → 

    Arrives next day

    Itabus S.p.A.ATM Azienda di Trasporti Molisana S.p.A.21h 55m • 1 change

Departing Tuesday, November 17, 2026

  •  → 

    FlixBusATM Azienda di Trasporti Molisana S.p.A.17h 10m • 1 change
  •  → 

    Arrives next day

    Itabus S.p.A.ATM Azienda di Trasporti Molisana S.p.A.21h 55m • 1 change

Departing Wednesday, November 18, 2026

  •  → 

    FlixBusATM Azienda di Trasporti Molisana S.p.A.17h 10m • 1 change

Frequently asked questions

Want to know about travelling from Lyon to Isernia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Lyon to Isernia.ExpandLaunch map view
  • Distance: 1,183.9 km
  • Duration: 19h 42m

What companies run services between Lyon, France and Isernia, Italy?

You can take a bus from Lyon - Gerland Bus Station to Isernia via Roma, Autostazione Tiburtina in around 17h 50m.

Operators