The average bus between Luton and Manchester takes 4h 29m and the fastest bus takes 3h 30m. There is a bus service every few hours from Luton to Manchester. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Luton and Manchester. The earliest departure is at 12:05 AM at night, and the last departure from Luton is at 10:45 PM which arrives into Manchester at 2:15 AM. All services require a transfer, and take on average 4h 29m. The schedules shown below are for the next available departures.

4h 25m • 1 change

4h 30m • 1 change

4h 55m • 1 change

4h 35m • 1 change

6h 10m • 1 change

4h 40m • 1 change

4h 10m • 1 change

4h 5m • 1 change

6h 10m • 1 change

4h 40m • 1 change

4h 10m • 1 change

4h 5m • 1 change

6h 10m • 1 change

4h 40m • 1 change

4h 10m • 1 change

4h 5m • 1 change
Want to know about travelling from Luton to Manchester? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Luton to Manchester. However, there are services departing from Luton station and arriving at Manchester station via Manchester Central Coach Station station. The journey, including transfers, takes approximately 4h 29m.
Luton to Manchester bus services, operated by National Express, depart from Milton Keynes Coachway station.
Luton to Manchester bus services, operated by National Express, arrive at Manchester Central Coach Station.
Book your Luton to Manchester bus tickets online with National Express.
The distance between Luton and Manchester is 216.2 km. The road distance is 278 km.
National Express operates a bus from Milton Keynes Coachway to Manchester Central Coach Station every 30 minutes. Tickets cost £29–70 and the journey takes 3h 55m.