The average bus between Lugano and Siena takes 9h 31m and the fastest bus takes 7h 55m. The bus service runs several times per day from Lugano to Siena. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Lugano and Siena. The earliest departure is at 3:15 AM at night, and the last departure from Lugano is at 7:35 PM which arrives into Siena at 5:30 AM. All services require a transfer at Milano, Autostazione Lampugnano and take an average of 9h 31m. The schedules shown below are for the next available departures.


11h 5m • 2 changes


13h 20m • 2 changes
Arrives next day


9h 55m • 2 changes


11h 5m • 2 changes


13h 20m • 2 changes
Arrives next day


9h 55m • 2 changes


11h 5m • 2 changes


13h 20m • 2 changes
Arrives next day


9h 55m • 2 changes


11h 5m • 2 changes


13h 20m • 2 changes
Arrives next day


9h 55m • 2 changes
Want to know about travelling from Lugano to Siena? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Lugano to Siena. However, there are services departing from Lugano station and arriving at Siena station via Milan. The journey, including transfers, takes approximately 9h 31m.
Lugano to Siena bus services, operated by FlixBus, depart from Lugano station.
Lugano to Siena bus services, operated by FlixBus, arrive at Siena station.
Book your Lugano to Siena bus tickets online with FlixBus.
The distance between Lugano and Siena is 353.1 km. The road distance is 473 km.
You can take a bus from Lugano to Siena via Milano, Autostazione Lampugnano and Florence Villa Constanza Bus Station in around 8h 32m.