The average bus between Lucerne and Rome takes 13h 53m and the fastest bus takes 12h 20m. The bus service runs several times per day from Lucerne to Rome. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Lucerne and Rome. The earliest departure is at 5:15 AM in the morning, and the last departure from Lucerne is at 11:30 PM which arrives into Rome at 1:50 PM. All services require a transfer, and take on average 13h 53m. The schedules shown below are for the next available departures.

15h 5m • 1 change
Arrives next day

18h 25m • 1 change
Arrives next day

14h 20m • 1 change

15h 5m • 1 change
Arrives next day

18h 20m • 1 change
Arrives next day

14h 20m • 1 change
Arrives next day

18h 25m • 1 change
Arrives next day

14h 20m • 1 change
Want to know about travelling from Lucerne to Rome? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Lucerne to Rome. However, there are services departing from Lucerne station and arriving at Rome station via Milan. The journey, including transfers, takes approximately 13h 53m.
Lucerne to Rome bus services, operated by FlixBus, depart from Luzern station.
Lucerne to Rome bus services, operated by FlixBus, arrive at Roma, Autostazione Tiburtina station.
Book your Lucerne to Rome bus tickets online with FlixBus and TTI Leonettibus SRL.
The distance between Lucerne and Rome is 662 km. The road distance is 838 km.
You can take a bus from Luzern to Roma, Autostazione Tiburtina via Milano, Autostazione Lampugnano in around 12h 12m.