The average bus between Lucerne and Genoa takes 8h 36m and the fastest bus takes 7h 5m. The bus service runs several times per day from Lucerne to Genoa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Lucerne and Genoa. The earliest departure is at 5:15 AM in the morning, and the last departure from Lucerne is at 11:30 PM which arrives into Genoa at 10:25 AM. All services require a transfer, and take on average 8h 36m. The schedules shown below are for the next available departures.

9h 5m • 1 change

11h • 1 change
Arrives next day

10h 55m • 1 change

9h 5m • 1 change

11h • 1 change
Arrives next day

10h 55m • 1 change
Want to know about travelling from Lucerne to Genoa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Lucerne to Genoa. However, there are services departing from Lucerne station and arriving at Genoa station via Milan. The journey, including transfers, takes approximately 8h 36m.
Lucerne to Genoa bus services, operated by FlixBus, depart from Luzern station.
Lucerne to Genoa bus services, operated by FlixBus, arrive at Genoa station.
Book your Lucerne to Genoa bus tickets online with FlixBus.
The distance between Lucerne and Genoa is 298.3 km. The road distance is 383 km.
You can take a bus from Luzern to Genoa via Milano, Autostazione Lampugnano in around 6h 25m.