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Lowell to Chicago buses

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Trip Overview

The average bus between Lowell and Chicago takes 40h 8m and the fastest bus takes 35h 20m. The bus runs, on average, 5 times per week from Lowell to Chicago. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

40h 8m
Duration
1,222 mi
Distance
$241
Average price
5 times a week
Frequency

Lowell to Chicago bus times

Buses run 5 times a week between Lowell and Chicago. The service departs Lowell at 7:50 PM in the evening, which arrives into Chicago at 06:10:00. All services require a transfer at Boston and take an average of 40h 8m. The schedules shown below are for the next available departures.

Departing Monday, November 2, 2026

  •  → 

    Arrives +3 days

    Greyhound USAGreyhound USAFlixbus USA2d 11h • 2 changes

Departing Thursday, November 5, 2026

  •  → 

    Arrives +2 days

    Greyhound USAGreyhound USAFlixbus USA35h 20m • 2 changes

Departing Friday, November 6, 2026

  •  → 

    Arrives +2 days

    Greyhound USAGreyhound USAFlixbus USA35h 20m • 2 changes

Departing Saturday, November 7, 2026

  •  → 

    Arrives +2 days

    Greyhound USAGreyhound USAFlixbus USA35h 20m • 2 changes

Frequently asked questions

Want to know about travelling from Lowell to Chicago? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Lowell to Chicago.ExpandLaunch map view
  • Distance: 1,221.9 mi
  • Duration: 40h 8m

What companies run services between Lowell, MA, USA and Chicago, IL, USA?

You can take a bus from Robert B Kennedy Bus Transfer Center to Chicago Bus Station via Boston and Newark Penn Station in around 27h 45m.

Operators