The average bus between Lecce and Guidonia takes 11h 51m and the fastest bus takes 9h 58m. The bus service runs several times per day from Lecce to Guidonia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Lecce and Guidonia. The earliest departure is at 12:05 PM in the afternoon, and the last departure from Lecce is at 9:00 PM which arrives into Guidonia at 6:58 AM. All services require a transfer at Rome Tiburtina Largo Mazzoni and take an average of 11h 51m. The schedules shown below are for the next available departures.
Arrives next day


12h 58m • 2 changes
Arrives next day


9h 58m • 2 changes
Arrives next day


17h 53m • 2 changes
Arrives next day


9h 58m • 2 changes
Arrives next day


12h 58m • 2 changes
Arrives next day


9h 58m • 2 changes
Want to know about travelling from Lecce to Guidonia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Lecce to Guidonia. However, there are services departing from Lecce station and arriving at Guidonia station via Rome Tiburtina Largo Mazzoni. The journey, including transfers, takes approximately 11h 51m.
Lecce to Guidonia bus services, operated by FlixBus, depart from Lecce Central Bus Station.
Lecce to Guidonia bus services, operated by FlixBus, arrive at Rome Tiburtina Largo Mazzoni station.
Book your Lecce to Guidonia bus tickets online with FlixBus, Cotral S.p.A. and ATAC S.p.A. Azienda per la mobilità.
The distance between Lecce and Guidonia is 491.3 km. The road distance is 607 km.
Itabus S.p.A. operates a bus from Lecce Central Bus Station to Rome Tiburtina Largo Mazzoni once daily. Tickets cost €35–75 and the journey takes 8h 30m.