The average bus between Kale and Istanbul takes 13h 13m and the fastest bus takes 12h 30m. The bus service runs several times per day from Kale to Istanbul. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Kale and Istanbul. The earliest departure is at 11:15 AM in the morning, and the last departure from Kale is at 10:15 PM which arrives into Istanbul at 12:00 PM. All services require a transfer, and take on average 13h 13m. The schedules shown below are for the next available departures.

12h 30m • 1 change
Arrives next day

13h 30m • 1 change
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13h 45m • 1 change

12h 30m • 1 change
Arrives next day

13h 30m • 1 change
Arrives next day

13h 45m • 1 change

12h 30m • 1 change
Arrives next day

13h 15m • 1 change
Arrives next day

13h 45m • 1 change

12h 30m • 1 change
Arrives next day

13h 15m • 1 change
Arrives next day

13h 45m • 1 change

12h 30m • 1 change
Arrives next day

13h 15m • 1 change
Arrives next day

13h 45m • 1 change
Want to know about travelling from Kale to Istanbul? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Kale to Istanbul. However, there are services departing from Kale station and arriving at Istanbul station via Denizli. The journey, including transfers, takes approximately 13h 13m.
Kale to Istanbul bus services, operated by Pamukkale Turizm, depart from Kale station.
Kale to Istanbul bus services, operated by Pamukkale Turizm, arrive at İstanbul Esenler station.
The distance between Kale and Istanbul is 397.6 km. The road distance is 673 km.
You can take a bus from Kale to İstanbul Esenler via Denizli in around 11h 34m.