The average bus between Kalamazoo and St. Louis takes 12h 55m and the fastest bus takes 11h 55m. The bus service runs several times per day from Kalamazoo to St. Louis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Kalamazoo and St. Louis. The earliest departure is at 3:15 AM at night, and the last departure from Kalamazoo is at 7:30 PM which arrives into St. Louis at 6:25 AM. All services require a transfer, and take on average 12h 55m. The schedules shown below are for the next available departures.

12h 25m • 1 change

11h 10m • 1 change
Arrives next day

10h 55m • 1 change

12h 25m • 1 change

11h 10m • 1 change
Arrives next day

10h 55m • 1 change
Want to know about travelling from Kalamazoo to St. Louis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Kalamazoo to St. Louis. However, there are services departing from Kalamazoo station and arriving at St. Louis station via Chicago Bus Station station. The journey, including transfers, takes approximately 12h 55m.
Kalamazoo to St. Louis bus services, operated by Greyhound USA, depart from Kalamazoo Bus Stop station.
Kalamazoo to St. Louis bus services, operated by Greyhound USA, arrive at St Louis Bus Station.
Book your Kalamazoo to St. Louis bus tickets online with Greyhound USA and Flixbus USA.
The distance between Kalamazoo and St. Louis is 563.9 km. The road distance is 746 km.
You can take a bus from Kalamazoo Bus Stop to St Louis Bus Station via Chicago Bus Station in around 9h 50m.