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Jacksonville to Key Largo buses

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Trip Overview

The average bus between Jacksonville and Key Largo takes 17h 7m and the fastest bus takes 14h 35m. There is at least one bus per day from Jacksonville to Key Largo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

17h 7m
Duration
472 mi
Distance
$104
Average price
Once daily
Frequency

Jacksonville to Key Largo bus times

Buses run once daily between Jacksonville and Key Largo. The earliest departure is at 10:30 AM in the morning, and the last departure from Jacksonville is at 3:50 PM which arrives into Key Largo at 6:25 AM. All services require a transfer, and take on average 17h 7m. The schedules shown below are for the next available departures.

Departing Friday, November 6, 2026

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    Arrives next day

    Flixbus USAGreyhound USA19h 55m • 1 change

Departing Saturday, November 7, 2026

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    Arrives next day

    Flixbus USAGreyhound USA14h 35m • 1 change

Departing Sunday, November 8, 2026

  •  → 

    Arrives next day

    Flixbus USAGreyhound USA14h 35m • 1 change

Departing Monday, November 9, 2026

  •  → 

    Arrives next day

    Flixbus USAGreyhound USA19h 55m • 1 change

Departing Tuesday, November 10, 2026

  •  → 

    Arrives next day

    Flixbus USAGreyhound USA14h 35m • 1 change

Departing Wednesday, November 11, 2026

  •  → 

    Arrives next day

    Flixbus USAGreyhound USA14h 35m • 1 change

Frequently asked questions

Want to know about travelling from Jacksonville to Key Largo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Jacksonville to Key Largo.ExpandLaunch map view
  • Distance: 472.3 mi
  • Duration: 17h 7m

What companies run services between Jacksonville, FL, USA and Key Largo, FL, USA?

You can take a bus from Jacksonville to Key Largo Bus Stop via Miami Airport Station in around 11h 40m.

Operators