Rome2Rio

Irvine to Milwaukee buses

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Trip Overview

The average bus between Irvine and Milwaukee takes 2d 18h and the fastest bus takes 2d 11h. The bus runs, on average, 4 times per week from Irvine to Milwaukee. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

2d 18h
Duration
2,366 mi
Distance
$490
Average price
4 times a week
Frequency

Irvine to Milwaukee bus times

Buses run 4 times a week between Irvine and Milwaukee. The earliest departure is at 5:45 AM in the morning, and the last departure from Irvine is at 11:45 PM which arrives into Milwaukee at 11:50 PM. All services require a transfer at Artic - Dock 4 and take an average of 2d 18h. The schedules shown below are for the next available departures.

Departing Saturday, November 14, 2026

  •  → 

    Arrives +3 days

    OCTAFlixbus USAGreyhound USAFlixbus USAGreyhound USA2d 22h • 4 changes

Departing Tuesday, November 17, 2026

  •  → 

    Arrives +3 days

    OCTAFlixbus USAGreyhound USAFlixbus USAGreyhound USA3d • 4 changes
  •  → 

    Arrives +3 days

    OCTAFlixbus USAGreyhound USAFlixbus USAFlixbus USA2d 17h • 4 changes

Frequently asked questions

Want to know about travelling from Irvine to Milwaukee? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Irvine to Milwaukee.ExpandLaunch map view
  • Distance: 2,365.5 mi
  • Duration: 2d 18h

What companies run services between Irvine, CA, USA and Milwaukee, WI, USA?

You can take a bus from Main-Harvard to Milwaukee Intermodal Station via Artic - Dock 4, Anaheim Regional Transportation Intermodal Center, Los Angeles Union Station, St Louis Bus Station, and Chicago Bus Station in around 2d 6h.

Operators