Rome2Rio

Indianapolis to Rochester buses

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Trip Overview

The bus between Indianapolis and Rochester takes 22h 35m. The bus runs, on average, 6 times per week from Indianapolis to Rochester. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

22h 35m
Duration
594 mi
Distance
$128
Average price
6 times a week
Frequency

Indianapolis to Rochester bus times

Buses run 6 times a week between Indianapolis and Rochester. The service departs Indianapolis at 11:05 AM in the morning, which arrives into Rochester at 09:40:00. All services require a transfer at Toledo Bus Stop and take an average of 22h 35m. The schedules shown below are for the next available departures.

Departing Friday, November 13, 2026

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    Arrives next day

    Greyhound USAGreyhound USAGreyhound USA22h 35m • 2 changes

Departing Saturday, November 14, 2026

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    Arrives next day

    Greyhound USAGreyhound USAGreyhound USA22h 35m • 2 changes

Departing Sunday, November 15, 2026

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    Arrives next day

    Greyhound USAGreyhound USAGreyhound USA22h 35m • 2 changes

Departing Monday, November 16, 2026

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    Arrives next day

    Greyhound USAGreyhound USAGreyhound USA22h 35m • 2 changes

Departing Tuesday, November 17, 2026

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    Arrives next day

    Greyhound USAGreyhound USAGreyhound USA22h 35m • 2 changes

Frequently asked questions

Want to know about travelling from Indianapolis to Rochester? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Indianapolis to Rochester.ExpandLaunch map view
  • Distance: 594.2 mi
  • Duration: 22h 35m

What companies run services between Indianapolis, IN, USA and Rochester, NY, USA?

You can take a bus from Indianapolis Union Station to Rochester Bus Stop via Toledo Bus Stop and Cleveland Bus Station in around 13h 15m.

Operators