The average bus between Hyannis and Brookline takes 2h 22m and the fastest bus takes 2h 12m. There is a bus service every few hours from Hyannis to Brookline. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Hyannis and Brookline. The earliest departure is at 4:00 AM at night, and the last departure from Hyannis is at 9:00 PM which arrives into Brookline at 11:16 PM. All services require a transfer at Boston, Bus Terminal South Station and take an average of 2h 22m. The schedules shown below are for the next available departures.

2h 21m • 1 change

2h 18m • 1 change

2h 18m • 1 change

2h 21m • 1 change

2h 14m • 1 change

2h 19m • 1 change

2h 19m • 1 change

2h 26m • 1 change

2h 36m • 1 change

2h 14m • 1 change

2h 12m • 1 change

2h 24m • 1 change

2h 15m • 1 change

2h 19m • 1 change

2h 26m • 1 change

2h 20m • 1 change
Want to know about travelling from Hyannis to Brookline? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Hyannis to Brookline. However, there are services departing from Hyannis station and arriving at Brookline station via Boston South Buses. The journey, including transfers, takes approximately 2h 22m.
Hyannis to Brookline bus services, operated by Plymouth & Brockton, depart from Hyannis Transportation Center station.
Hyannis to Brookline bus services, operated by Plymouth & Brockton, arrive at Boston South Buses station.
The distance between Hyannis and Brookline is 102.4 km. The road distance is 121 km.
Plymouth & Brockton operates a bus from Hyannis Transportation Center to Boston South Buses hourly. Tickets cost $27–35 and the journey takes 1h 50m.