The average bus between Hyannis and Bethesda takes 12h 5m and the fastest bus takes 10h 50m. The bus service runs several times per day from Hyannis to Bethesda. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Hyannis and Bethesda. The earliest departure is at 5:00 AM in the morning, and the last departure from Hyannis is at 9:00 PM which arrives into Bethesda at 12:15 PM. All services require a transfer at Boston, South Station and take an average of 12h 5m. The schedules shown below are for the next available departures.


10h 50m • 2 changes


11h 5m • 2 changes


11h 10m • 2 changes
Arrives next day


18h 40m • 2 changes


10h 50m • 2 changes


11h 5m • 2 changes


11h 10m • 2 changes
Arrives next day


15h 15m • 2 changes


11h 50m • 2 changes


11h 5m • 2 changes


11h 10m • 2 changes
Arrives next day


15h 15m • 2 changes
Want to know about travelling from Hyannis to Bethesda? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Hyannis to Bethesda. However, there are services departing from Hyannis station and arriving at Bethesda station via Boston South Buses. The journey, including transfers, takes approximately 12h 5m.
Hyannis to Bethesda bus services, operated by Plymouth & Brockton, depart from Hyannis Transportation Center station.
Hyannis to Bethesda bus services, operated by Plymouth & Brockton, arrive at Bethesda station.
Book your Hyannis to Bethesda bus tickets online with Plymouth & Brockton and Flixbus USA.
The distance between Hyannis and Bethesda is 649.7 km. The road distance is 897 km.
You can take a bus from Hyannis Transportation Center to Bethesda via Boston, South Station, Boston, and New York Midtown in around 12h 1m.