The average bus between Houston and Des Moines takes 25h 40m and the fastest bus takes 22h 40m. The bus service runs several times per day from Houston to Des Moines. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Houston and Des Moines. The earliest departure is at 10:35 AM in the morning, and the last departure from Houston is at 6:00 PM which arrives into Des Moines at 10:45 PM. All services require a transfer at Dallas Bus Station and take an average of 25h 40m. The schedules shown below are for the next available departures.
Arrives next day


22h 40m • 2 changes
Arrives next day


28h 45m • 2 changes
Arrives next day


22h 40m • 2 changes
Arrives next day


28h 45m • 2 changes
Arrives next day


22h 40m • 2 changes
Arrives next day


28h 45m • 2 changes
Want to know about travelling from Houston to Des Moines? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Houston to Des Moines. However, there are services departing from Houston station and arriving at Des Moines station via Dallas Bus Station station. The journey, including transfers, takes approximately 25h 40m.
Houston to Des Moines bus services, operated by Flixbus USA, depart from Downtown Houston station.
Houston to Des Moines bus services, operated by Flixbus USA, arrive at Des Moines station.
The distance between Houston and Des Moines is 1,325.7 km. The road distance is 1,625 km.
You can take a bus from Downtown Houston to Des Moines via Dallas Bus Station and Kansas City in around 21h 30m.