The average bus between Hoboken and Hyannis takes 6h 49m and the fastest bus takes 6h 25m. The bus service runs several times per day from Hoboken to Hyannis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Hoboken and Hyannis. The earliest departure is at 1:30 AM at night, and the last departure from Hoboken is at 2:30 PM which arrives into Hyannis at 9:35 PM. All services require a transfer at Boston and take an average of 6h 49m. The schedules shown below are for the next available departures.

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Want to know about travelling from Hoboken to Hyannis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Hoboken to Hyannis. However, there are services departing from Hoboken station and arriving at Hyannis station via Boston. The journey, including transfers, takes approximately 6h 49m.
Hoboken to Hyannis bus services, operated by Flixbus USA, depart from New York Midtown station.
Hoboken to Hyannis bus services, operated by Flixbus USA, arrive at Hyannis Transportation Center station.
The distance between Hoboken and Hyannis is 329.2 km. The road distance is 458 km.
You can take a bus from New York Midtown to Hyannis Transportation Center via Boston and Boston South Station in around 6h 55m.