The average bus between Guelph and Brantford takes 2h 42m and the fastest bus takes 2h 13m. The bus service runs several times per day from Guelph to Brantford. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Guelph and Brantford. The earliest departure is at 5:46 AM in the morning, and the last departure from Guelph is at 8:50 PM which arrives into Brantford at 11:03 PM. All services require a transfer, and take on average 2h 42m. The schedules shown below are for the next available departures.

2h 18m • 1 change

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2h 48m • 1 change

2h 53m • 1 change

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2h 48m • 1 change

2h 53m • 1 change

2h 18m • 1 change

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2h 48m • 1 change

2h 53m • 1 change

2h 18m • 1 change

2h 21m • 1 change

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2h 53m • 1 change
Want to know about travelling from Guelph to Brantford? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Guelph to Brantford. However, there are services departing from Guelph station and arriving at Brantford station via McMaster University. The journey, including transfers, takes approximately 2h 42m.
Guelph to Brantford bus services, operated by GO Transit, depart from Guelph Central GO Bus station.
Guelph to Brantford bus services, operated by GO Transit, arrive at Brantford Bus Terminal station.
The distance between Guelph and Brantford is 45.9 km. The road distance is 98 km.
You can take a bus from Guelph Central GO Bus to Brantford Bus Terminal via McMaster University in around 2h 58m.