The average bus between Frederick and Manhattan takes 6h 31m and the fastest bus takes 4h 50m. The bus service runs several times per day from Frederick to Manhattan. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Frederick and Manhattan. The earliest departure is at 5:05 AM in the morning, and the last departure from Frederick is at 7:15 PM which arrives into Manhattan at 12:05 AM. All services require a transfer, and take on average 6h 31m. The schedules shown below are for the next available departures.

7h 35m • 1 change
6h 40m • 1 changeArrives next day

4h 50m • 1 change
7h 35m • 1 change
6h 40m • 1 changeArrives next day

4h 50m • 1 change
7h 35m • 1 change
6h 40m • 1 changeArrives next day

4h 50m • 1 change
7h 35m • 1 change
6h 40m • 1 changeArrives next day

4h 50m • 1 changeWant to know about travelling from Frederick to Manhattan? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Frederick to Manhattan. However, there are services departing from Frederick station and arriving at Manhattan station via Baltimore Downtown Bus Terminal, Baltimore, MD. The journey, including transfers, takes approximately 6h 31m.
Frederick to Manhattan bus services, operated by Greyhound USA, depart from Frederick Bus Station.
Frederick to Manhattan bus services, operated by Greyhound USA, arrive at Port Authority Bus Terminal station.
Book your Frederick to Manhattan bus tickets online with Greyhound USA and BayRunner Shuttle.
The distance between Frederick and Manhattan is 330.1 km. The road distance is 460 km.
You can take a bus from Frederick Bus Station to Port Authority Bus Terminal via Baltimore Downtown Bus Station in around 5h 25m.