The average bus between Frederick and Charlotte takes 12h 36m and the fastest bus takes 10h 30m. The bus service runs several times per day from Frederick to Charlotte. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Frederick and Charlotte. The earliest departure is at 12:35 AM at night, and the last departure from Frederick is at 10:25 AM which arrives into Charlotte at 12:45 AM. All services require a transfer, and take on average 12h 36m. The schedules shown below are for the next available departures.

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10h 30m • 1 change

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14h 20m • 1 change
Want to know about travelling from Frederick to Charlotte? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Frederick to Charlotte. However, there are services departing from Frederick station and arriving at Charlotte station via Washington Union Station station. The journey, including transfers, takes approximately 12h 36m.
Frederick to Charlotte bus services, operated by Greyhound USA, depart from Frederick Bus Station.
Frederick to Charlotte bus services, operated by Greyhound USA, arrive at Charlotte Bus Station.
Book your Frederick to Charlotte bus tickets online with Greyhound USA and Flixbus USA.
The distance between Frederick and Charlotte is 555.7 km. The road distance is 718 km.
You can take a bus from Frederick Bus Station to Charlotte Bus Station via Washington Union Station in around 10h 5m.