Rome2Rio

Durham to Louisville buses

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Trip Overview

The bus between Durham and Louisville takes 37h 5m. The bus runs, on average, 6 times per week from Durham to Louisville. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

37h 5m
Duration
806 mi
Distance
$160
Average price
6 times a week
Frequency

Durham to Louisville bus times

Buses run 6 times a week between Durham and Louisville. The service departs Durham at 4:55 AM at night, which arrives into Louisville at 18:00:00. All services require a transfer at Atlanta Downtown and take an average of 37h 5m. The schedules shown below are for the next available departures.

Departing Sunday, November 15, 2026

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    Arrives next day

    Greyhound USASunway ChartersBarons BusGreyhound USAAmtrak Thruway37h 5m • 4 changes

Departing Monday, November 16, 2026

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    Arrives next day

    Greyhound USASunway ChartersBarons BusGreyhound USAAmtrak Thruway37h 5m • 4 changes

Departing Tuesday, November 17, 2026

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    Arrives next day

    Greyhound USASunway ChartersBarons BusGreyhound USAAmtrak Thruway37h 5m • 4 changes

Departing Wednesday, November 18, 2026

  •  → 

    Arrives next day

    Greyhound USASunway ChartersBarons BusGreyhound USAAmtrak Thruway37h 5m • 4 changes

Departing Thursday, November 19, 2026

  •  → 

    Arrives next day

    Greyhound USASunway ChartersBarons BusGreyhound USAAmtrak Thruway37h 5m • 4 changes

Frequently asked questions

Want to know about travelling from Durham to Louisville? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Durham to Louisville.ExpandLaunch map view
  • Distance: 805.8 mi
  • Duration: 37h 5m

What companies run services between Durham, NC, USA and Louisville, KY, USA?

You can take a bus from Durham to Louisville, KY via Atlanta Downtown, Civic Center Station, Garnett Station, Atlanta Bus Station, and Nashville in around 16h 34m.

Operators