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Des Moines to Santa Ana buses

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Trip Overview

The bus between Des Moines and Santa Ana takes 41h 55m. The bus runs, on average, 6 times per week from Des Moines to Santa Ana. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

41h 55m
Duration
1,712 mi
Distance
$358
Average price
6 times a week
Frequency

Des Moines to Santa Ana bus times

Buses run 6 times a week between Des Moines and Santa Ana. The service departs Des Moines at 7:35 PM in the evening, which arrives into Santa Ana at 11:30:00. All services require a transfer at Denver Union Station and take an average of 41h 55m. The schedules shown below are for the next available departures.

Departing Sunday, November 15, 2026

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    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound USA41h 55m • 2 changes

Departing Monday, November 16, 2026

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    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound USA41h 55m • 2 changes

Departing Tuesday, November 17, 2026

  •  → 

    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound USA41h 55m • 2 changes

Departing Wednesday, November 18, 2026

  •  → 

    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound USA41h 55m • 2 changes

Departing Thursday, November 19, 2026

  •  → 

    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound USA41h 55m • 2 changes

Frequently asked questions

Want to know about travelling from Des Moines to Santa Ana? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Des Moines to Santa Ana.ExpandLaunch map view
  • Distance: 1,712.4 mi
  • Duration: 41h 55m

What companies run services between Des Moines, IA, USA and Santa Ana, CA, USA?

You can take a bus from Des Moines to Santa Ana Bus Stop via Denver Union Station and Las Vegas Bus Terminal in around 37h 20m.

Operators