The average bus between Des Moines and Houston takes 28h 16m and the fastest bus takes 21h 50m. There is at least one bus per day from Des Moines to Houston. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run once daily between Des Moines and Houston. The earliest departure is at 6:30 PM in the evening, and the last departure from Des Moines is at 11:45 PM which arrives into Houston at 12:05 PM. All services require a transfer at Kansas City Bus Station and take an average of 28h 16m. The schedules shown below are for the next available departures.
Arrives next day


21h 50m • 2 changes
Arrives +2 days


36h 20m • 2 changes
Arrives next day


21h 50m • 2 changes
Arrives +2 days


36h 20m • 2 changes
Arrives next day


21h 50m • 2 changes
Arrives +2 days


36h 20m • 2 changes
Want to know about travelling from Des Moines to Houston? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Des Moines to Houston. However, there are services departing from Des Moines station and arriving at Houston station via Kansas City. The journey, including transfers, takes approximately 28h 16m.
Des Moines to Houston bus services, operated by Jefferson Lines, depart from Des Moines station.
Des Moines to Houston bus services, operated by Jefferson Lines, arrive at Downtown Houston station.
The distance between Des Moines and Houston is 1,325.7 km. The road distance is 1,631 km.
You can take a bus from Des Moines to Downtown Houston via Kansas City Bus Station and Dallas Bus Station in around 22h 40m.