The average bus between Deptford and Manchester takes 6h 31m and the fastest bus takes 5h 10m. There is a bus service every few hours from Deptford to Manchester. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Deptford and Manchester. The earliest departure is at 12:05 AM at night, and the last departure from Deptford is at 11:55 PM which arrives into Manchester at 7:35 AM. All services require a transfer at Baker Street Station and take an average of 6h 31m. The schedules shown below are for the next available departures.


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5h 55m • 2 changesWant to know about travelling from Deptford to Manchester? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Deptford to Manchester. However, there are services departing from Deptford Bridge station and arriving at Shudehill Interchange station via Baker Street Station. The journey, including transfers, takes approximately 6h 31m.
Deptford to Manchester bus services, operated by Go Ahead London, depart from Deptford Bridge station.
Deptford to Manchester bus services, operated by FlixBus, arrive at Shudehill Interchange station.
The distance between Deptford and Manchester is 268.7 km. The road distance is 306 km.
You can take a bus from Deptford Bridge to Shudehill Interchange via Baker Street Station, Baker Street station, Finchley Road station, and Finchley Road / O2 Centre in around 6h 35m.