The average bus between Denver and Jacksonville takes 45h 7m and the fastest bus takes 39h 40m. The bus service runs several times per day from Denver to Jacksonville. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Denver and Jacksonville. The earliest departure is at 1:20 PM in the afternoon, and the last departure from Denver is at 7:25 PM which arrives into Jacksonville at 11:05 PM. All services require a transfer at St Louis Bus Station and take an average of 45h 7m. The schedules shown below are for the next available departures.
Arrives +2 days


41h 40m • 2 changes
Arrives +2 days


2d 3h • 2 changes
Arrives +2 days


41h 40m • 2 changes
Arrives +2 days


2d 3h • 2 changes
Want to know about travelling from Denver to Jacksonville? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Denver to Jacksonville. However, there are services departing from Denver station and arriving at Jacksonville station via St Louis Bus Station station. The journey, including transfers, takes approximately 45h 7m.
Denver to Jacksonville bus services, operated by Greyhound USA, depart from Denver Union Station.
Denver to Jacksonville bus services, operated by Greyhound USA, arrive at Jacksonville station.
Book your Denver to Jacksonville bus tickets online with Greyhound USA and Flixbus USA.
The distance between Denver and Jacksonville is 2,357.9 km. The road distance is 2,911 km.
You can take a bus from Denver Union Station to Jacksonville via St Louis Bus Station and Atlanta Bus Station in around 37h 5m.