The average bus between Chicago and Calexico takes 46h 44m and the fastest bus takes 42h 50m. The bus service runs several times per day from Chicago to Calexico. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Chicago and Calexico. The earliest departure is at 12:15 AM at night, and the last departure from Chicago is at 5:15 PM which arrives into Calexico at 2:25 PM. All services require a transfer at St Louis Bus Station and take an average of 46h 44m. The schedules shown below are for the next available departures.
Arrives next day


40h 50m • 2 changes
Arrives +2 days


45h 10m • 2 changes
Arrives next day


40h 50m • 2 changes
Arrives +2 days


45h 10m • 2 changes
Arrives next day


40h 50m • 2 changes
Arrives +2 days


45h 10m • 2 changes
Want to know about travelling from Chicago to Calexico? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Chicago to Calexico. However, there are services departing from Chicago station and arriving at Calexico station via St Louis Bus Station station. The journey, including transfers, takes approximately 46h 44m.
Chicago to Calexico bus services, operated by Flixbus USA, depart from Chicago Bus Station.
Chicago to Calexico bus services, operated by Flixbus USA, arrive at Calexico Bus Station.
Book your Chicago to Calexico bus tickets online with Flixbus USA and Greyhound USA.
The distance between Chicago and Calexico is 2,654.6 km. The road distance is 3,371 km.
You can take a bus from Chicago Bus Station to Calexico Bus Station via St Louis Bus Station and Phoenix Bus Station in around 42h 25m.