The average bus between Cheb and Brno takes 6h and the fastest bus takes 5h 20m. The bus service runs several times per day from Cheb to Brno. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Cheb and Brno. The earliest departure is at 5:00 AM in the morning, and the last departure from Cheb is at 7:00 PM which arrives into Brno at 1:05 AM. All services require a transfer, and take on average 6h. The schedules shown below are for the next available departures.

6h 20m • 1 change

6h • 1 change

5h 40m • 1 change
Arrives next day

6h 5m • 1 change

6h 55m • 1 change

6h • 1 change

5h 40m • 1 change
Arrives next day

6h 5m • 1 change

6h 55m • 1 change

6h • 1 change

5h 20m • 1 change
Arrives next day

6h 5m • 1 change

6h 20m • 1 change

6h • 1 change

5h 20m • 1 change
Arrives next day

6h 5m • 1 change

6h 20m • 1 change

6h • 1 change

6h 20m • 1 change

5h 20m • 1 change
Want to know about travelling from Cheb to Brno? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Cheb to Brno. However, there are services departing from Cheb station and arriving at Brno station via Praha, ÚAN Florenc. The journey, including transfers, takes approximately 6h.
Cheb to Brno bus services, operated by RegioJet, depart from Cheb station.
Cheb to Brno bus services, operated by RegioJet, arrive at Brno station.
Book your Cheb to Brno bus tickets online with RegioJet and FlixBus.
The distance between Cheb and Brno is 320.3 km. The road distance is 390 km.
You can take a bus from Cheb to Brno via Praha, ÚAN Florenc in around 5h 49m.