The bus between Cdmx and Tlaxco takes 2h 59m. The bus service runs several times per day from Cdmx to Tlaxco. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Cdmx and Tlaxco. The earliest departure is at 6:30 AM in the morning, and the last departure from Cdmx is at 6:30 PM which arrives into Tlaxco at 9:30 PM. All services require a transfer at Museo San Carlos and take an average of 2h 59m. The schedules shown below are for the next available departures.

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Want to know about travelling from Cdmx to Tlaxco? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Cdmx to Tlaxco. However, there are services departing from Cdmx station and arriving at Tlaxco station via Tlaxco. The journey, including transfers, takes approximately 2h 59m.
Cdmx to Tlaxco bus services, operated by Metrobús, depart from Terminal de Autobuses de Pasajeros de Oriente station.
Cdmx to Tlaxco bus services, operated by Metrobús, arrive at Tlaxco station.
The distance between Cdmx and Tlaxco is 110 km. The road distance is 131 km.
Autotransportes Tlaxcala, Apizaco, Huamantla, S.A. de C.V. operates a bus from Terminal de Autobuses de Pasajeros de Oriente to Tlaxco every 4 hours. Tickets cost $55–300 and the journey takes 2h 30m.