Cardinal Hotel St. Peter, Rome to Florence Buses

Cardinal Hotel St. Peter, Rome to Florence buses

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Trip Overview

The average bus between Cardinal Hotel St. Peter, Rome and Florence takes 4h 35m and the fastest bus takes 4h 5m. There is a bus service every few hours from Cardinal Hotel St. Peter, Rome to Florence. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4h 35m
Duration: 290 km
Distance: €40
Average price: Hourly
Frequency

Line 490 bus, bus

best

Take the bus from Emo/Di Bartolo to Roma, Autostazione Tiburtinabus 490 / ...
Take the bus from Roma, Autostazione Tiburtina to Florence Villa Constanza Bus Stationbus 510 / ...

4h 49m

€16–52

Cardinal Hotel St. Peter, Rome to Florence bus times

Buses run hourly between Cardinal Hotel St. Peter, Rome and Florence. The earliest departure is at 5:25 AM in the morning, and the last departure from Cardinal Hotel St. Peter, Rome is at 9:54 PM which arrives into Florence at 2:10 AM. All services require a transfer at Leone Xiii/Pio Xi and take an average of 4h 35m. The schedules shown below are for the next available departures.

Departing Monday, October 19, 2026

3:20 PM → 7:50 PM
4h 29m • 2 changes
3:41 PM → 8:15 PM
4h 33m • 2 changes
4:28 PM → 9:15 PM
4h 47m • 2 changes
6:04 PM → 10:30 PM
4h 25m • 2 changes
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Departing Tuesday, October 20, 2026

5:25 AM → 10:15 AM
4h 49m • 2 changes
6:50 AM → 11:10 AM
4h 19m • 2 changes
7:03 AM → 11:45 AM
4h 41m • 2 changes
7:29 AM → 12:15 PM
4h 45m • 2 changes
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Departing Wednesday, October 21, 2026

6:50 AM → 11:10 AM
4h 19m • 2 changes
7:03 AM → 11:45 AM
4h 41m • 2 changes
7:29 AM → 12:15 PM
4h 45m • 2 changes
8:20 AM → 12:45 PM
4h 24m • 2 changes
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Departing Thursday, October 22, 2026

5:25 AM → 10:15 AM
4h 49m • 2 changes
6:50 AM → 11:10 AM
4h 19m • 2 changes
7:03 AM → 11:45 AM
4h 41m • 2 changes
7:29 AM → 12:15 PM
4h 45m • 2 changes
Show more

Frequently asked questions

Want to know about travelling from Cardinal Hotel St. Peter, Rome to Florence? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

What companies run services between Cardinal Hotel St. Peter, Rome, Italy and Florence, Italy?

You can take a vehicle from Cardinal Hotel St. Peter, Rome to Florence Villa Constanza Bus Station via Leone Xiii/Pio Xi, Anastasio Ii/Pieralice, Emo/Di Bartolo, and Roma, Autostazione Tiburtina in around 4h 49m.

Operators