The average bus between Cape Cod and Brookline takes 4h 3m and the fastest bus takes 2h 46m. The bus service runs several times per day from Cape Cod to Brookline. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 2 hours between Cape Cod and Brookline. The earliest departure is at 6:34 AM in the morning, and the last departure from Cape Cod is at 8:46 PM which arrives into Brookline at 6:15 AM. All services require a transfer at Hyannis Transportation Center and take an average of 4h 3m. The schedules shown below are for the next available departures.


3h 34m • 2 changes


3h 45m • 2 changes


3h 32m • 2 changes


3h 41m • 2 changes


2h 46m • 2 changes


3h 47m • 2 changes


3h 32m • 2 changes


3h 32m • 2 changes


2h 46m • 2 changes


3h 47m • 2 changes


3h 32m • 2 changes


3h 32m • 2 changes


2h 46m • 2 changes


3h 47m • 2 changes


3h 32m • 2 changes


3h 32m • 2 changes
Want to know about travelling from Cape Cod to Brookline? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Cape Cod to Brookline. However, there are services departing from Cape Cod station and arriving at Brookline station via Boston South Buses. The journey, including transfers, takes approximately 4h 3m.
Cape Cod to Brookline bus services, operated by Cape Cod Regional Transit Authority, depart from Hyannis Transportation Center station.
Cape Cod to Brookline bus services, operated by Cape Cod Regional Transit Authority, arrive at Boston South Buses station.
The distance between Cape Cod and Brookline is 105.1 km. The road distance is 130 km.
Plymouth & Brockton operates a bus from Hyannis Transportation Center to Boston South Buses hourly. Tickets cost $27–35 and the journey takes 1h 50m.