The average bus between Buffalo and Mastic takes 14h 22m and the fastest bus takes 13h 38m. The bus service runs several times per day from Buffalo to Mastic. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Buffalo and Mastic. The earliest departure is at 5:30 AM in the morning, and the last departure from Buffalo is at 11:59 PM which arrives into Mastic at 3:41 PM. All services require a transfer at New York Midtown and take an average of 14h 22m. The schedules shown below are for the next available departures.
Arrives next day




13h 38m • 4 changes
Arrives next day




15h 42m • 4 changes




14h 13m • 4 changes




13h 43m • 4 changes
Arrives next day




14h 38m • 4 changes
Arrives next day




15h 42m • 4 changes




14h 13m • 4 changes




13h 43m • 4 changes
Arrives next day




13h 38m • 4 changes
Arrives next day




15h 42m • 4 changes
Want to know about travelling from Buffalo to Mastic? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Buffalo to Mastic. However, there are services departing from Buffalo station and arriving at Mastic station via New York Midtown. The journey, including transfers, takes approximately 14h 22m.
Buffalo to Mastic bus services, operated by Flixbus USA, depart from Buffalo station.
Buffalo to Mastic bus services, operated by Flixbus USA, arrive at Old Country Rd/Tanger Mall Dr station.
The distance between Buffalo and Mastic is 551 km. The road distance is 902 km.
You can take a bus from Buffalo to Mastic Rd/Patchogue Ave via New York Midtown, W 42 St/Broadway, E 42 St/Lexington Av, 41st St bet 3rd & Lex, Old Country Rd/Tanger Mall Dr, and Riverhead LIRR in around 13h 15m.