The average bus between Buffalo and Manlius takes 6h 22m and the fastest bus takes 5h 11m. The bus service runs several times per day from Buffalo to Manlius. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Buffalo and Manlius. The earliest departure is at 12:55 AM at night, and the last departure from Buffalo is at 8:45 PM which arrives into Manlius at 6:06 AM. All services require a transfer at Syracuse Bus Station and take an average of 6h 22m. The schedules shown below are for the next available departures.


6h 16m • 2 changes


5h 25m • 2 changes


5h 35m • 2 changes


5h 11m • 2 changes


6h 16m • 2 changes


5h 25m • 2 changes


5h 35m • 2 changes


5h 11m • 2 changes


6h 16m • 2 changes


5h 25m • 2 changes


5h 35m • 2 changes


5h 11m • 2 changes


6h 16m • 2 changes


5h 25m • 2 changes


5h 35m • 2 changes


5h 11m • 2 changes
Want to know about travelling from Buffalo to Manlius? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Buffalo to Manlius. However, there are services departing from Buffalo station and arriving at Manlius station via Syracuse Bus Station station. The journey, including transfers, takes approximately 6h 22m.
Buffalo to Manlius bus services, operated by Greyhound USA, depart from Buffalo station.
Buffalo to Manlius bus services, operated by Greyhound USA, arrive at Syracuse Bus Station.
The distance between Buffalo and Manlius is 236.5 km. The road distance is 279 km.
Flixbus USA operates a bus from Buffalo to Syracuse Bus Station every 4 hours. Tickets cost $19–35 and the journey takes 2h 50m. Two other operators also service this route.