The average bus between Buffalo and Harlem takes 9h and the fastest bus takes 8h 34m. The bus service runs several times per day from Buffalo to Harlem. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Buffalo and Harlem. The earliest departure is at 6:00 AM in the morning, and the last departure from Buffalo is at 11:15 PM which arrives into Harlem at 7:52 AM. All services require a transfer, and take on average 9h. The schedules shown below are for the next available departures.

9h 10m • 1 change

9h 18m • 1 change

8h 42m • 1 change
Arrives next day

8h 37m • 1 change

9h 15m • 1 change

9h 26m • 1 change

8h 52m • 1 change
Arrives next day

8h 37m • 1 change

9h 26m • 1 change

8h 52m • 1 change
Arrives next day

8h 37m • 1 change

9h 26m • 1 change

8h 52m • 1 change
Arrives next day

8h 37m • 1 change
Want to know about travelling from Buffalo to Harlem? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Buffalo to Harlem. However, there are services departing from Buffalo station and arriving at Harlem station via New York. The journey, including transfers, takes approximately 9h.
Buffalo to Harlem bus services, operated by Trailways, depart from Buffalo station.
Buffalo to Harlem bus services, operated by Trailways, arrive at New York station.
The distance between Buffalo and Harlem is 469.3 km. The road distance is 746 km.
Trailways operates a bus from Buffalo to New York 5 times a day. Tickets cost $60–280 and the journey takes 7h 55m.