The average bus between Buffalo and Des Moines takes 25h 50m and the fastest bus takes 20h 50m. The bus service runs several times per day from Buffalo to Des Moines. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Buffalo and Des Moines. The earliest departure is at 7:55 AM in the morning, and the last departure from Buffalo is at 11:05 PM which arrives into Des Moines at 6:55 PM. All services require a transfer at Cleveland Bus Station and take an average of 25h 50m. The schedules shown below are for the next available departures.
Arrives next day


30h 40m • 2 changes
Arrives next day


19h 50m • 2 changes
Arrives next day


30h 40m • 2 changes
Arrives next day


19h 50m • 2 changes
Arrives next day


30h 40m • 2 changes
Arrives next day


19h 50m • 2 changes
Arrives next day


30h 40m • 2 changes
Arrives next day


19h 50m • 2 changes
Want to know about travelling from Buffalo to Des Moines? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Buffalo to Des Moines. However, there are services departing from Buffalo station and arriving at Des Moines station via Cleveland Bus Station station. The journey, including transfers, takes approximately 25h 50m.
Buffalo to Des Moines bus services, operated by Greyhound USA, depart from Buffalo station.
Buffalo to Des Moines bus services, operated by Greyhound USA, arrive at Des Moines station.
Book your Buffalo to Des Moines bus tickets online with Greyhound USA.
The distance between Buffalo and Des Moines is 1,219.4 km. The road distance is 1,413 km.
You can take a bus from Buffalo to Des Moines via Cleveland Bus Station and Chicago Bus Station in around 19h 25m.