The average bus between Brussels and Wertheim takes 11h 52m and the fastest bus takes 9h 15m. The bus service runs several times per day from Brussels to Wertheim. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Brussels and Wertheim. The earliest departure is at 6:20 AM in the morning, and the last departure from Brussels is at 6:30 PM which arrives into Wertheim at 12:26 PM. All services require a transfer at Frankfurt central train station and take an average of 11h 52m. The schedules shown below are for the next available departures.


10h 58m • 2 changes


10h 5m • 2 changes
Arrives next day


13h 7m • 2 changes


10h 58m • 2 changes


10h 5m • 2 changes
Arrives next day


13h 7m • 2 changes


10h 58m • 2 changes


10h 5m • 2 changes
Arrives next day


13h 7m • 2 changes


10h 58m • 2 changes


9h 15m • 2 changes
Arrives next day


12h 29m • 2 changes
Arrives next day


15h 58m • 2 changes
Want to know about travelling from Brussels to Wertheim? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Brussels to Wertheim. However, there are services departing from Brussels station and arriving at Wertheim station via Frankfurt central train station station. The journey, including transfers, takes approximately 11h 52m.
Brussels to Wertheim bus services, operated by FlixBus, depart from Brussels-North train station.
Brussels to Wertheim bus services, operated by FlixBus, arrive at Wertheim, ZOB station.
The distance between Brussels and Wertheim is 385.9 km. The road distance is 555 km.
You can take a bus from Brussels-North train station to Wertheim, ZOB via Frankfurt central train station and Würzburg, Hauptbahnhof ZOB in around 10h 5m.