The average bus between Brighton and Slough takes 2h 34m and the fastest bus takes 2h 12m. There is an hourly bus service from Brighton to Slough. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Brighton and Slough. The earliest departure is at 3:05 AM at night, and the last departure from Brighton is at 10:50 PM which arrives into Slough at 1:51 AM. All services require a transfer, and take on average 2h 34m. The schedules shown below are for the next available departures.

2h 29m • 1 change

2h 44m • 1 change

2h 37m • 1 change

2h 23m • 1 change

2h 12m • 1 change

2h 32m • 1 change

2h 36m • 1 change

2h 40m • 1 change

2h 12m • 1 change

2h 32m • 1 change

2h 36m • 1 change

2h 40m • 1 change
Want to know about travelling from Brighton to Slough? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Brighton to Slough. However, there are services departing from Brighton station and arriving at Slough station via Heathrow Terminal 5. The journey, including transfers, takes approximately 2h 34m.
Brighton to Slough bus services, operated by National Express, depart from Preston Circus station.
Brighton to Slough bus services, operated by National Express, arrive at Heathrow Terminal 5 station.
Book your Brighton to Slough bus tickets online with National Express, Thames Valley Buses and 2 other operators.
The distance between Brighton and Slough is 82.1 km. The road distance is 114 km.
National Express operates a bus from Preston Circus to Heathrow Terminal 5 hourly. Tickets cost £11–28 and the journey takes 1h 53m. FlixBus also services this route 4 times a day.