The average bus between Brantford and Guelph takes 2h 34m and the fastest bus takes 1h 55m. The bus service runs several times per day from Brantford to Guelph. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Brantford and Guelph. The earliest departure is at 5:15 AM in the morning, and the last departure from Brantford is at 7:55 PM which arrives into Guelph at 10:27 PM. All services require a transfer, and take on average 2h 34m. The schedules shown below are for the next available departures.

2h 14m • 1 change

2h 33m • 1 change

2h 35m • 1 change

2h 58m • 1 change

2h 14m • 1 change

2h 33m • 1 change

2h 35m • 1 change

2h 58m • 1 change

2h 14m • 1 change

2h 33m • 1 change

2h 35m • 1 change

2h 58m • 1 change

2h 14m • 1 change

2h 33m • 1 change

2h 35m • 1 change

2h 58m • 1 change
Want to know about travelling from Brantford to Guelph? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Brantford to Guelph. However, there are services departing from Brantford station and arriving at Guelph station via McMaster University. The journey, including transfers, takes approximately 2h 34m.
Brantford to Guelph bus services, operated by GO Transit, depart from Brantford Bus Terminal station.
Brantford to Guelph bus services, operated by GO Transit, arrive at Guelph Central GO Bus station.
The distance between Brantford and Guelph is 45.9 km. The road distance is 97 km.
You can take a bus from Brantford Bus Terminal to Guelph Central GO Bus via McMaster University in around 3h.