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Boston to Santa Fe Depot buses

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Trip Overview

The average bus between Boston and Santa Fe Depot takes 3d 17h and the fastest bus takes 3d 15h. The bus runs, on average, 4 times per week from Boston to Santa Fe Depot. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

3d 17h
Duration
3,277 mi
Distance
4 times a week
Frequency

Boston to Santa Fe Depot bus times

Buses run 4 times a week between Boston and Santa Fe Depot. The earliest departure is at 3:05 PM in the afternoon, and the last departure from Boston is at 5:15 PM which arrives into Santa Fe Depot at 5:35 AM. All services require a transfer at Newark Penn Station and take an average of 3d 17h. The schedules shown below are for the next available departures.

Departing Monday, November 9, 2026

  •  → 

    Arrives +4 days

    Flixbus USAGreyhound USAGreyhound USAAmtrak3d 15h • 3 changes

Departing Tuesday, November 10, 2026

  •  → 

    Arrives +4 days

    Greyhound USAGreyhound USAGreyhound USAAmtrak3d 17h • 3 changes

Departing Wednesday, November 11, 2026

  •  → 

    Arrives +4 days

    Greyhound USAGreyhound USAGreyhound USAAmtrak3d 17h • 3 changes

Frequently asked questions

Want to know about travelling from Boston to Santa Fe Depot? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Boston to Santa Fe Depot.ExpandLaunch map view
  • Distance: 3,277.1 mi
  • Duration: 3d 17h

What companies run services between Boston, MA, USA and Santa Fe Depot, San Diego County, CA, USA?

You can take a bus from Boston to San Diego via Newark Penn Station, St Louis Bus Station, Los Angeles Union Station, and Los Angeles in around 3d 1h.

Operators