The average bus between Boston and Middlesex takes 7h 2m and the fastest bus takes 6h 5m. The bus service runs several times per day from Boston to Middlesex. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 3 hours between Boston and Middlesex. The earliest departure is at 5:30 AM in the morning, and the last departure from Boston is at 8:30 PM which arrives into Middlesex at 8:00 AM. All services require a transfer, and take on average 7h 2m. The schedules shown below are for the next available departures.

7h 4m • 1 change

7h 4m • 1 change

6h 54m • 1 change

6h 35m • 1 change

7h 4m • 1 change

7h 4m • 1 change

7h 4m • 1 change

6h 32m • 1 change

6h 38m • 1 change

6h 28m • 1 change

6h 23m • 1 change

6h 53m • 1 change

6h 51m • 1 change

6h 51m • 1 change

6h 51m • 1 change

6h 50m • 1 change
Want to know about travelling from Boston to Middlesex? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Boston to Middlesex. However, there are services departing from Boston station and arriving at Middlesex station via Port Authority Bus Terminal. The journey, including transfers, takes approximately 7h 2m.
Boston to Middlesex bus services, operated by Peter Pan Bus Lines, depart from South Station.
Boston to Middlesex bus services, operated by Peter Pan Bus Lines, arrive at Boundbrook Rd At John F. Kennedy Dr station.
The distance between Boston and Middlesex is 348.2 km. The road distance is 483 km.
You can take a bus from South Station to Boundbrook Rd At John F. Kennedy Dr via Port Authority Bus Terminal in around 6h 51m.