The average bus between Boston and Middlesex takes 6h 39m and the fastest bus takes 5h 58m. There is a bus service every few hours from Boston to Middlesex. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 2 hours between Boston and Middlesex. The earliest departure is at 1:00 AM at night, and the last departure from Boston is at 7:30 PM which arrives into Middlesex at 1:58 AM. All services require a transfer at New York Midtown and take an average of 6h 39m. The schedules shown below are for the next available departures.

6h 39m • 1 change

6h 44m • 1 change

6h 15m • 1 change

6h 42m • 1 change

7h • 1 change

7h 30m • 1 change

6h 49m • 1 change

7h 4m • 1 change

7h • 1 change

7h 30m • 1 change

6h 49m • 1 change

6h 39m • 1 change

7h • 1 change

6h 49m • 1 change

7h 4m • 1 change

6h 39m • 1 change

7h • 1 change

6h 49m • 1 change

7h 4m • 1 change

6h 39m • 1 change
Want to know about travelling from Boston to Middlesex? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Boston to Middlesex. However, there are services departing from Boston station and arriving at Middlesex station via New York Midtown. The journey, including transfers, takes approximately 6h 39m.
Boston to Middlesex bus services, operated by Flixbus USA, depart from Boston station.
Boston to Middlesex bus services, operated by Flixbus USA, arrive at Boundbrook Rd At John F. Kennedy Dr station.
The distance between Boston and Middlesex is 348.2 km. The road distance is 480 km.
You can take a bus from Boston to Boundbrook Rd At John F. Kennedy Dr via New York Midtown and Port Authority Bus Terminal in around 6h 47m.